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The division of antibiotics, like other drugs, into groups and classes is well known. Such a division is of great importance from the point of view of understanding the spectrum of activity, pharmacokinetic features, the nature of undesirable drug reactions, etc. However, it is wrong to consider all drugs that are in the same group (class, generation) as interchangeable. There may be significant differences between drugs of the same generation and differing only in one molecule. For example, http://canadaonpharm.com/buy-prednisone-online/ among cephalosporins of the third generation, only ceftazidime and cefoperazone have clinically significant activity against Pseudomonas aeruginosa. Therefore, even when in vitro data is obtained on the sensitivity of the pyocyanic stick to Cefotaxime or Ceftriaxone, these drugs should not be used to treat this infection, since the results of clinical trials indicate a high incidence of failure. Another example is the difference in the pharmacokinetics of antibacterial drugs: first-generation cephalosporins (cefazolin) cannot be used in the treatment of bacterial meningitis, due to poor permeability through the BBB.